Cyclo-oxygenase-2 Messenger RNA Induction in Focal Cerebral Ischemia

induction of focal cerebral ischemia by continuous recording of cerebral blood flow using laser doppler flowmeter in rat

background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...

Induction of type 2 iodothyronine deiodinase in astrocytes after transient focal cerebral ischemia in the rat.

This study investigated the expression of deiodinases of thyroid hormones in the rat brain after transient occlusion of the middle cerebral artery. The activity of type 2 deiodinase (D2), which catalyzes the deiodination of thyroxine into the more active thyroid hormone 3,5,3'-triiodothyronine, was strongly increased by cerebral ischemia at 6 and 24 hours in the striatum and at 24 hours in the ...

Induction of cyclo-oxygenase and nitric oxide synthase in inflammation.

Focal Cerebral Ischemia

We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat The right middle cerebral artery and common carotid artery were occluded for 0,1 ,2 ,3 ,4 , or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and edema volumes were quantified in serial frozen sections of hematoxylin and eosin-s...

Involvement of tyrosine kinases in the induction of cyclo-oxygenase-2 in human endothelial cells.

In addition to a constitutive cyclo-oxygenase (Cox-1), human endothelial cells also possess an inducible cyclo-oxygenase (Cox-2) which plays an important role in the regulation of the synthesis of prostacyclin (prostaglandin I2). Cox-2 is regulated and expressed in large quantities upon activation of the cells by inducers such as phorbol myristate acetate (PMA), an activator of protein kinase C...